Kalender onder voorbehoud van wijzigingen!
| Speeldag | Datum | Uur | Wedstrijd | Score |
| 1. | Zon. 25/07/2021 | 16:00 | FCB – Eupen | 2 – 2 |
| 2. | Zon. 01/08/2021 | 13:30 | Union – FCB | 0 – 1 |
| 3. | Vrij. 06/08/2021 | 20:45 | FCB – Cercle Brugge | 1 – 1 |
| 4. | Zon. 15/08/2021 | 21:00 | Zulte Waregem – FCB | 0 – 4 |
| 5. | Zon. 22/08/2021 | 18:30 | FCB – Beerschot | 3 – 2 |
| 6. | Zon. 29/08/2021 | 13:30 | AA Gent – FCB | 6 – 1 |
| 7. | Vrij. 10/09/2021 | 20:45 | FCB – KV Oostende | 3 – 0 |
| 8. | Zat. 18/09/2021 | 20:45 | Charleroi – FCB | 0 – 1 |
| 9. | Vrij. 24/09/2021 | 20:45 | FCB – OH Leuven | 1 – 1 |
| 10. | Zon. 03/10/2021 | 13:30 | Anderlecht – FCB | 1 – 1 |
| 11. | Vrij. 15/10/2021 | 20:45 | FCB – KV Kortrijk | 2 – 0 |
| 12. | Zon. 24/10/2021 | 13:30 | Antwerp – FCB | – |
| 13. | Zat. 30/10/2021 | 20:45 | Sint-Truiden – FCB | – |
| 14. | Zon. 07/11/2021 | 13:30 | FCB – Standard | – |
| 15. | Vrij. 19/11/2021 | 20:45 | KV Mechelen – FCB | – |
| 16. | Zon. 28/11/2021 | 13:30 | Racing Genk – FCB | – |
| 17. | … | …:… | FCB – Seraing | – |
| 18. | … | …:… | FCB – Zulte Waregem | – |
| 19. | … | …:… | OH Leuven – FCB | – |
| 20. | … | …:… | FCB – Anderlecht | – |
| 21. | … | …:… | Cercle Brugge – FCB | – |
| 22. | … | …:… | FCB – Sint-Truiden | |
| 23. | … | …:… | Standard – FCB | – |
| 24. | … | …:… | FCB – Union | – |
| 25. | … | …:… | KV Kortrijk – FCB | – |
| 26. | … | …:… | FCB – AA Gent | – |
| 27. | … | …:… | FCB – Charleroi | – |
| 28. | … | …:… | Eupen – FCB | – |
| 29. | … | …:… | FCB – Antwerp | – |
| 30. | … | …:… | Seraing – FCB | – |
| 31. | … | …:… | KV Oostende – FCB | – |
| 32. | … | …:… | FCB – Racing Genk | – |
| 33. | … | …:… | Beerschot – FCB | – |
| 34. | … | …:… | FCB – KV Mechelen | – |
